A Controlled Porosity Osmotic Pump System with Biphasic Release of Theophylline
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چکیده
منابع مشابه
Feasibility of optimizing trimetazidine dihydrochloride release from controlled porosity osmotic pump tablets of directly compressed cores
The aim of this study was to develop and optimize Trimetazidine dihydrochloride (TM) controlled porosity osmotic pump (CPOP) tablets of directly compressed cores. A 2(3) full factorial design was used to study the influence of three factors namely: PEG400 (10% and 25% based on coating polymer weight), coating level (10% and 20% of tablet core weight) and hole diameter (0 "no hole" and 1 mm). Ot...
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BACKGROUND The osmotic drug delivery systems suitable for oral administration typically consist of a compressed tablet core that is coated with a semipermeable membrane that has an orifice drilled on it by means of a laser beam or mechanical drill. Ketorolac is a nonsteroidal agent with powerful analgesic. Oral bioavailability of ketorolac was reported to be 90% with very low hepatic first-pass...
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Aim: The objective of this study was to identify critical formulation parameters affecting the drug release from controlled porosity osmotic tablet of milnacipran hydrochloride employing the concept of design of experiments. Materials and Methods: The optimized amount of ethocel (X1) and mannitol (X2) in core and percentage of sorbitol (X3) in coat were determined employing a three-factor, thre...
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Controlled porosity osmotic tablet of carvedilol phosphate prepared and evaluated in this study. Carvedilol phosphate is very low soluble drug. So it is difficult to formulate osmotic tablet of carvedilol phosphate which gives drug release up to 24 hr at zero order. To get desired dissolution profile various formulation parameters like osmogen concentration, level of weight gain and level of po...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2007
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.55.1574